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Filtering by: Creator Levy, Joseph Remove constraint Creator: Levy, Joseph Advisor Beckman, Joseph S. Remove constraint Advisor: Beckman, Joseph S. Language English [eng] Remove constraint Language: English [eng]

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  • Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

    Creator:
    Rhoads, Timothy W.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
    Resource Type:
    Dissertation
    Full Text:
    : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by

  • Revealing sequences and modifications of intact proteins using electron fragmentation

    Creator:
    Franklin, Rachel
    Abstract:
    People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: ______________________________________________________ Joseph S. Beckman

  • The detection of superoxide and implications for amyotrophic lateral sclerosis

    Creator:
    Robinson, Kristine M.
    Abstract:
    Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Joseph S. Beckman Mutations to superoxide dismutase were the first proven cause of Lou