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Filtering by: Committee Member Greenwood, Jeffery A Advisor Beckman, Joseph S.

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:

Rhoads, Timothy W.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...

Resource Type:

Dissertation

Full Text:

: Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by
The detection of superoxide and implications for amyotrophic lateral sclerosis

Creator:

Robinson, Kristine M.

Abstract:

Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...

Resource Type:

Dissertation

Full Text:

provide a stable source for in vitro experimentation. Second, the products from the peroxynitrite