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Filtering by: Creator Shaw, Mike Advisor Beckman, Joseph S.

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:

Meeuwsen, Joseph C.

Abstract:

Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...

Resource Type:

Dissertation

Full Text:

– especially Mike Hare, Diana Oppenheimer, Blake Hakkila, and Jared Shaw – it’s a thrill to work with such
Revealing sequences and modifications of intact proteins using electron fragmentation

Creator:

Franklin, Rachel

Abstract:

People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...

Resource Type:

Dissertation

Full Text:

getting me oriented in the laboratory. In particular, I would like to thank Mike Hare for teaching me
Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:

Rhoads, Timothy W.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...

Resource Type:

Dissertation

Full Text:

(# P30ES000210). Finally I have to thank my parents, John and Sharon, and my siblings, Mike and Emily, for