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Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Creator:: Chinison, Jessica J.
Abstract:: Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
Resource Type:: Masters Thesis
Full Text:: -cells and their proliferation, and decreases the expression of the co-stimulatory receptor B7.2 on B

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation
Full Text:: actin polymerization inhibitor, cytochalasin B, prior to infection inhibited the ability of MAH to

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: the mycobacterial cell wall. Alsteens, et al. [23]. B. Illustration highlighting the major

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Creator:: Everman, Jamie L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
Resource Type:: Dissertation
Full Text:: antibiotics amphotericin B, nalidixic acid, and vancomycin prior to culture on Middlebrook 7H10 agar

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Creator:: Armstrong, Elyssa L.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is the most common pathogen among non-tuberculous mycobacteria, causing disease in immunocompromised individuals. An intracellular bacterium, MAH resides within the phagosome, a vesicle formed by macrophages as they engulf invading pathogens. Here, a subpopulation of MAH regresses into a nonreplicative state called persistence, allowing them...
Resource Type:: Honors College Thesis
Full Text:: drug resistance. Cell host & microbe 13:632-642. 8. Wagner D, Maser J, Lai B, Cai Z, Barry CE, 3rd

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:: Joseph, Jayanthi J.
Abstract:: To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Resource Type:: Dissertation
Full Text:: al., 2008). Lymphocytes (T cells and B cells) and fibroblasts surround the core of the granuloma

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

Creator:: Chiplunkar, Sanket S.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) belongs to the most-clinically significant non-tuberculous mycobacterial (NTM) pathogens with constant increase in disease prevalence, mainly in several industrialized western countries where tuberculosis is less prevalent. Upon entry into the alveolar space, MAH is engulfed by resident-macrophages, where the pathogen adapts to the hostile phagosomal...
Resource Type:: Masters Thesis
Full Text:: infection (A) and uninfected control (B)…………………...……………………………………………………....98 9. List of host

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Creator:: Jha, Samradhni
Abstract:: Mycobacterium avium is a ubiquitous environmental organism found in water and soil. It can cause disease in patients with pre-existing pulmonary conditions, immunocompromised patients with the most prevalent being AIDS patients, as well as apparently healthy people. Studies have indicated that, upon macrophage uptake, Al. avium prevents phagosome-lysosome fusion, thus...
Resource Type:: Masters Thesis
Full Text:: 2% to 25% B in 30 minutes, then to 50% B in 35 mins, then 80% B in 40 mins and held there for 5

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation
Full Text:: B, Bottone EJ. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of

ScholarsArchive@OSU

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

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