Index Catalog // ScholarsArchive@OSU

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Creator:: Rose, Sasha J.
Abstract:: Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
Resource Type:: Dissertation
Full Text:: Sasha J. Rose for the degree of Doctor of Philosophy in Microbiology presented on March 15, 2016

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:: Joseph, Jayanthi J.
Abstract:: To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Jayanthi J. Joseph for the degree of Doctor of Philosophy in

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Michael J

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Creator:: Chinison, Jessica J.
Abstract:: Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
Resource Type:: Masters Thesis
Full Text:: for submission (1).docx AN ABSTRACT OF THE THESIS OF Jessica J. Chinison for the degree

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation
Full Text:: unlikely with rare exceptions (Olivier, Weber et al. 2003, Aitken, Limaye et al. 2012). 3

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Creator:: Armstrong, Elyssa L.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is the most common pathogen among non-tuberculous mycobacteria, causing disease in immunocompromised individuals. An intracellular bacterium, MAH resides within the phagosome, a vesicle formed by macrophages as they engulf invading pathogens. Here, a subpopulation of MAH regresses into a nonreplicative state called persistence, allowing them...
Resource Type:: Honors College Thesis
Full Text:: , dextrose, and catalase supplement (OADC; Hardy Diagnostics, Santa Maria, CA) at 37o for 7 to 14 days

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: W. J. (2017). Nontuberculous Mycobacteria-Overview. Microbiology spectrum, 5(1), 10.1128

Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

Creator:: Keefe, Bailey F.
Abstract:: Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
Resource Type:: Masters Thesis
Full Text:: W-J, Yew WW. 2016. Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Creator:: Lewis, Matthew S.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is an opportunistic pathogen that is ubiquitous in the environment and often isolated from faucets and showerheads. MAH mostly infects humans with an underlying disease, such as chronic pulmonary disorder (COPD), cystic fibrosis (CF), or are immunocompromised, though infections in patients without concurrent disease are...
Resource Type:: Masters Thesis
Full Text:: catalase (OADC) (Hardy Diagnostics) to log-phase at 37°C. Growth curves were conducted in Middlebrook

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Creator:: Everman, Jamie L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
Resource Type:: Dissertation
Full Text:: .................................................................................. 208 Appendix 2.3 Danelishvili L, Babrak L, Rose SJ, Everman J, Bermudez LE. 2014. Mycobacterium

ScholarsArchive@OSU

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Establishment of an in vitro System for Studying Mycobacterium avium Protein Secretion

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

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