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Creator:: Armstrong, Elyssa L.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is the most common pathogen among non-tuberculous mycobacteria, causing disease in immunocompromised individuals. An intracellular bacterium, MAH resides within the phagosome, a vesicle formed by macrophages as they engulf invading pathogens. Here, a subpopulation of MAH regresses into a nonreplicative state called persistence, allowing them...
Resource Type:: Honors College Thesis
Full Text:: preventing their contribution to chronic infection. 18 References 1. Chong YP, Park SJ, Kim

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: . M., Lee, J. Y., Kim, K. H., Shin, S. J., Takahara, K., Lee, S. J., & Jo, E. K. (2008

Creator:: Joseph, Jayanthi J.
Abstract:: To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Resource Type:: Dissertation
Full Text:: permissive for bacterial replication under these conditions (S.-W. Kim et al., 2017). Scope of

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation

Creator:: Chinison, Jessica J.
Abstract:: Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
Resource Type:: Masters Thesis
Full Text:: . Gordin, S. M. Holland, R. Horsburgh, G. Huitt, M. F. Lademarco, M. Iseman, K. Okivier, S. Ruoss, C. F

Creator:: Keefe, Bailey F.
Abstract:: Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
Resource Type:: Masters Thesis
Full Text:: :569–583. 12. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM

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