Index Catalog // ScholarsArchive@OSU

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Creator:: Armstrong, Elyssa L.
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) is the most common pathogen among non-tuberculous mycobacteria, causing disease in immunocompromised individuals. An intracellular bacterium, MAH resides within the phagosome, a vesicle formed by macrophages as they engulf invading pathogens. Here, a subpopulation of MAH regresses into a nonreplicative state called persistence, allowing them...
Resource Type:: Honors College Thesis
Full Text:: , dextrose, and catalase supplement (OADC; Hardy Diagnostics, Santa Maria, CA) at 37o for 7 to 14 days

Establishing Caenorhabditis elegans as a model for Mycobacterium avium subspecieshominissuis infection and intestinal colonization

Creator:: Ziaie, Navid
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) causes potentially lethal opportunistic infections in immunocompromised individuals. Lack of a good animal model system currently hinders in vivo study of MAH virulence. Here we applied the tractable organism Caenorhabditis elegans (C. elegans), as a surrogate host to study the virulence of MAH. Worms were...
Resource Type:: Honors College Thesis
Full Text:: -‐‑albumin-‐‑dextrose-‐‑catalase (OADC; Hardy Diagnostics; Santa Maria, CA) for 10 days at 37°C

Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

Creator:: Keefe, Bailey F.
Abstract:: Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
Resource Type:: Masters Thesis
Full Text:: , dextrose, and catalase (OADC; Hardy diagnostics, Santa Maria, CA) at 37 °C. Single cell bacterial

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Creator:: Everman, Jamie L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
Resource Type:: Dissertation
Full Text:: ::MAP1203 constructs ........................ 155 5.8 Expression and purification of N-terminal and C

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Creator:: Rose, Sasha J.
Abstract:: Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
Resource Type:: Dissertation
Full Text:: containing typical N-acetyl glucosamine and N-acetyl muramic acid molecules crosslinked by peptide bridges

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Creator:: Jha, Samradhni
Abstract:: Mycobacterium avium is a ubiquitous environmental organism found in water and soil. It can cause disease in patients with pre-existing pulmonary conditions, immunocompromised patients with the most prevalent being AIDS patients, as well as apparently healthy people. Studies have indicated that, upon macrophage uptake, Al. avium prevents phagosome-lysosome fusion, thus...
Resource Type:: Masters Thesis
Full Text:: respect to my late father Shri. Dhruva. N. Dharaskar for whatever I am today. He is the building block of

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: (Baltimore, Md.: 1950), 171(12), 6766– 6773. 22. Ramirez-Alejo, N., & Santos-Argumedo, L. (2014). Innate

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Creator:: Babrak, Lmar
Abstract:: Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
Resource Type:: Dissertation
Full Text:: MIP-1 protein and UBA/TS-N domain (gray)…………………………………………………………...96 3.2 MIP-1 interacts with host

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

Creator:: Chiplunkar, Sanket S.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) belongs to the most-clinically significant non-tuberculous mycobacterial (NTM) pathogens with constant increase in disease prevalence, mainly in several industrialized western countries where tuberculosis is less prevalent. Upon entry into the alveolar space, MAH is engulfed by resident-macrophages, where the pathogen adapts to the hostile phagosomal...
Resource Type:: Masters Thesis
Full Text:: of proline-glutamic acid and proline-proline- glutamic acid motifs present in the proximity of N

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: range of un- folded precursor proteins that contain a conserved N-terminal signal sequence (S/T- R-R-X

ScholarsArchive@OSU

Establishment of an in vitro model to study persistence in Mycobacterium avium subspecies hominissuis

Establishing Caenorhabditis elegans as a model for Mycobacterium avium subspecieshominissuis infection and intestinal colonization

Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search