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Filtering by: Creator Podolskiy, Viktor A. Remove constraint Creator: Podolskiy, Viktor A. Advisor Bovbjerg, Viktor E. Remove constraint Advisor: Bovbjerg, Viktor E. Contributor Damnernsawad, Alisa Remove constraint Contributor: Damnernsawad, Alisa

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  • Role of MEK Mutations in Trametinib Resistant Acute Myeloid Leukemia Cells

    Creator:
    Beer, Sofia R.
    Abstract:
    Acute myeloid leukemia (AML) is a blood malignancy characterized by a differentiation and proliferation defect of myeloid progenitors leading to accumulation of myeloid blasts. It is one of the most common leukemias in adults. Trametinib (Mekinist) is a small molecule inhibitor that targets MEK1 (MAP2K1) and MEK2 (MAPK2K2). It has...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _____________________________________________________ Viktor E. Bovbjerg Acute myeloid leukemia (AML) is a blood malignancy characterized by a