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Filtering by: Creator Sterba, George R. Advisor Buermeyer, Andrew Degree Field BioResource Research

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:

Kernan, Casey P.

Abstract:

DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...

Resource Type:

Honors College Thesis

Full Text:

150 R el at iv e Su rv iv al (% ) BPDE Dose (nM) DLD1 (MSH6-) DLD1+Ch2 (MSH6+) 0 50 100 150