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Filtering by: Creator Wang, Kuen Wu Advisor Buermeyer, Andrew Degree Name Honors Bachelor of Science (H.B.S.)

Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creator:

Wickramanayake, Anneka

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical compounds found in the environment, largely as a result of partial combustion of organic compounds. PAHs are present in the atmosphere in populated cities worldwide. Because of the health risks they create, PAHs are a global health concern. PAHs are introduced into the...

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Honors College Thesis

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macromolecules, including native DNA (Wu, 2003). This mechanism of activation, with modifications in certain
Investigating the Role of the MutLα Endonuclease

Creator:

Mankaney, Gautam Naresh

Abstract:

Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...

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Honors College Thesis

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using methods outlined by Wang (52) with some variations (Figure 5). The pRO1 plasmid was generously
DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:

Kernan, Casey P.

Abstract:

DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...

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Honors College Thesis

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complexes is essential for activation of successive MMR steps (Wang, 2006). The MutLα (MLH1·PMS2