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Filtering by: Advisor Buermeyer, Andrew File Format application/msword Peer Reviewed No

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:

O'Donnell, Edmond Francis

Abstract:

DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...

Resource Type:

Honors College Thesis
Investigating the Role of the MutLα Endonuclease

Creator:

Mankaney, Gautam Naresh

Abstract:

Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...

Resource Type:

Honors College Thesis