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Filtering by: Alternative title ssim Circular of information no. 664 Remove constraint Alternative title ssim: Circular of information no. 664 Advisor Buermeyer, Andrew Remove constraint Advisor: Buermeyer, Andrew File Format application/msword Remove constraint File Format: application/msword

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  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    , no homolog of MutH, which creates the strand signal needed for excision in E. coli, has been

  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    is inevitable that the accurate information content of the genome degrades over time; the