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Filtering by: Creator Center, O. D Remove constraint Creator: Center, O. D Advisor Buermeyer, Andrew Remove constraint Advisor: Buermeyer, Andrew File Format application/msword Remove constraint File Format: application/msword

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  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    D < 1 A Mutation rates (mutations/cell/generation) were calculated as described in materials