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Filtering by: Alternative title ssim Special report 627 Remove constraint Alternative title ssim: Special report 627 Advisor Buermeyer, Andrew Remove constraint Advisor: Buermeyer, Andrew File Format application/msword Remove constraint File Format: application/msword

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  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    special importance. Although MutLα plays a critical role in MMR, the molecular functions of the protein