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Filtering by: Advisor Buermeyer, Andrew Resource Type Presentation

Creating Isogenic Cell Cultures for Functional Studies of DNA Mismatch-Repair

Creator:

Sarver, Kimberly

Abstract:

Colorectal cancer (CRC), the third leading cause of cancer death in the USA, depends on early detection for patient survival. Early detection is improved with the identification of high risk individuals. Risk of CRC development is a complex interaction between an individual’s genetics and environmental exposures. Polycyclic Aromatic Hydrocarbons (PAHs)...

Resource Type:

Undergraduate Thesis and Presentation
Gene-Environment Interactions In Hereditary Colorectal Cancer Risk

Creator:

Almousawi, Fatimah Hussain

Abstract:

Cancer economic impact is enormous and depending on the stage in which a colon cancer is detected, five-year survival rates for colon cancer may be as high as 74%, or as low as 6% (American Cancer Society, 2012). Thus early prevention of colon cancer is crucial to maximize the chances...

Resource Type:

Undergraduate Thesis and Presentation
DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:

Kernan, Casey P.

Abstract:

DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...

Resource Type:

Presentation and Undergraduate Thesis