Index Catalog // ScholarsArchive@OSU

Creator:: Larkey, Nicholas E.
Abstract:: One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
Resource Type:: Dissertation
Full Text:: . ©Copyright by Nicholas E. Larkey May 22, 2017 All Rights Reserved Displacement-based

Creator:: Smith, Natasha M.
Abstract:: In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
Resource Type:: Honors College Thesis
Full Text:: Associate) Presented May 9 2016 Commencement June 2016

Creator:: Tran, Victoria
Abstract:: Micro-ribonucleic acids (miRNA) are becoming an increasingly popular topic of research in hopes of discovering newfound biomarkers and/or therapies for numerous types of cancers and diseases. MiRNA are a type of biomolecule contributing to the progression of multiple cancers and diseases, and such biomolecules are called biomarkers. Current RNA-based biosensors...
Resource Type:: Honors College Thesis
Full Text:: Associate) Presented May 28th, 2015 Commencement June 2015

Creator:: Almlie, C. Kyle
Abstract:: Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
Resource Type:: Dissertation
Full Text:: friends in graduate school: Drs. Whitney Schmidt, Chris Heist, Ryne Johnston, and Nicholas Larkey were

Creator:: Zhang, Lulu
Abstract:: Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
Resource Type:: Dissertation
Full Text:: Ziebart, Margie Haak, Paula Weiss, and Kristi Edwards. I would like to thank my lab mates Nicholas

Creator:: Zhou, Lixia
Abstract:: Tethering fluorophores on metal nanoparticles for metal enhanced fluorescence (MEF) has attracted a lot of attention from scientists interested in fluorescence based approaches. MEF has many benefits in fluorescence related techniques, because the analytical signal increases and enables potentially lower detection limits or better sensitivity. Many types of nanoparticles have...
Resource Type:: Dissertation
Full Text:: : Kyle Almlie, Nicholas Larkey, Lulu Zhang, Kuan-Jen Chen, Shan Lansing, Jake Ramsey, Annie Bluhm

ScholarsArchive@OSU