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Filtering by: Alternative title ssim 4-H 962 Advisor Carter, Rich G. Committee Member Blakemore, Paul R.

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:

Mahapatra, Subham

Abstract:

More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...

Resource Type:

Dissertation

Full Text:

CO2Me H OTBS OTBS 3 steps Bu3Sn Mo(CO)3(NCtBu)3 Bu3SnH, THF 86%, 4:1 rr 1.44 1.50 1.48 1.46
A Diels-Alder approach to biaryl synthesis

Creator:

Ashburn, Bradley O.

Abstract:

An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...

Resource Type:

Dissertation

Full Text:

provide increased potency. 4 EtO O NSAID - Antiarthritic (1.8) N CO2H O N N N H N