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Filtering by: Creator Rochelle, Michael Remove constraint Creator: Rochelle, Michael Advisor Carter, Rich G. Remove constraint Advisor: Carter, Rich G. Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • Studies toward the total synthesis of azaspiracid-1

    Creator:
    Kuiper, Damien L.
    Abstract:
    Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
    Resource Type:
    Dissertation
    Full Text:
    Heteroatom Michael Approach to the FGHI ring sysem….…………...……………. 11 1.9: Nicolaou!s Approach to the FGHI

  • Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

    Creator:
    Li, Jinming
    Abstract:
    Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
    Resource Type:
    Dissertation
    Full Text:
    1.3.2 may arise from hetero-Michael cyclization of thioester 1.3.3 to build the 2,6-cis