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Filtering by: Alternative title ssim EC 333 Advisor Cheeke, Peter R. Decade 1970-1979

Selenium effects and species differences in hepatic metabolism of pyrrolizidine alkaloids and other xenobiotics

Creator:

Shull, Lee R.

Abstract:

The metabolism of pyrrolizidine alkaloids and other drugs was studied with regard to nutritional status and species differences. Pyrrolizidine alkaloids which are biotransformed to severely toxic metabolites were isolated from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid crystals containing five alkaloids (senecionine, seneciophylline, jacobine, jacoline, and jacozine) were prepared and found...

Resource Type:

Dissertation
Dietary factors influencing the toxicity of tansy ragwort (Senecio jacobaea) in animals

Creator:

Swick, Robert Alphonso

Abstract:

Senecio jacobaea (tansy ragwort) is a poisonous plant responsible for livestock deaths in the Pacific Northwest. Horses and cattle are susceptible, while sheep are resistant to the toxic action of the pyrrolizidine alkaloids which the plant contains. Hepatic enzymes are responsible for the biotransformation of pyrrolizidine alkaloids into tissue damaging...

Resource Type:

Masters Thesis