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Dietary factors influencing the toxicity of tansy ragwort (Senecio jacobaea) in animals

Creator:: Swick, Robert Alphonso
Abstract:: Senecio jacobaea (tansy ragwort) is a poisonous plant responsible for livestock deaths in the Pacific Northwest. Horses and cattle are susceptible, while sheep are resistant to the toxic action of the pyrrolizidine alkaloids which the plant contains. Hepatic enzymes are responsible for the biotransformation of pyrrolizidine alkaloids into tissue damaging...
Resource Type:: Masters Thesis
Full Text:: indicate that tansy ragwort is not detoxified as a result of sheep rumen fermentation. In Part C, the

Factors affecting the toxicity of Senecio jacobea to laboratory animals

Creator:: Pierson, Mary Louisa
Resource Type:: Masters Thesis
Full Text:: Alkaloids 20 (a) Cattle 20 (b) Horses 22 (c) Sheep 23 (d) Swine 25 (e) Avian Species 26 (f) Rabbits 28 (g

Nutritional influences affecting senecio toxicity in laboratory animals

Creator:: Buckmaster, Gary Wayne
Abstract:: The objective of this research project was to evaluate the toxicity of local pyrrolizidine alkaloid containing plants and to examine the influence of dietary protein, with particular reference to the amino acid cysteine, upon this toxicity. Senecio vulgaris (common groundsel) was shown to be more toxic than Senecio jacobaea (tansy...
Resource Type:: Masters Thesis
Full Text:: . C. Lewis where goats were killed by feeding 2 to 3 ounces of fresh Crotalaria straita leaves. Tilt

Determination of the transfer of pyrrolizidine alkaloids into goats milk by biological assay

Creator:: Goeger, Douglas Eugene
Resource Type:: Masters Thesis
Full Text:: Laboratory for the histopathological work, and R. A. Swick and J. C. Throck- morton for help in the animal

Selenium effects and species differences in hepatic metabolism of pyrrolizidine alkaloids and other xenobiotics

Creator:: Shull, Lee R.
Abstract:: The metabolism of pyrrolizidine alkaloids and other drugs was studied with regard to nutritional status and species differences. Pyrrolizidine alkaloids which are biotransformed to severely toxic metabolites were isolated from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid crystals containing five alkaloids (senecionine, seneciophylline, jacobine, jacoline, and jacozine) were prepared and found...
Resource Type:: Dissertation
Full Text:: appreciation to my wife, Kathi, who never ceased to be understanding and encouraging. To Dr. C. N. Skrepetos

Mutagenic and toxicologic implications of pyrrolizidine (Senecio) alkaloids

Creator:: White, Randy Dee
Abstract:: The Salmonella/mammalian-microsome mutagenicity test was used to evaluate Senecio jacobaea (SJ) plant, Pyrrolizidine alkaloids (PA) and metabolites in goat milk, to evaluate response differences with microsomes from several animal species and to compare SJ plant responses to other plants. Bioassessment experiments were conducted to evaluate PA toxicity changes associated with...
Resource Type:: Dissertation
Full Text:: linkages. Bifunctional alkylating agents of this type can be compared to nitrogen mustards and mitomycin C

Senecio jacobaea : toxicity and effects on mineral metabolism in animals

Creator:: Swick, Robert Alphonso
Abstract:: Several experiments were conducted to examine the toxicity of Senecio jacobaea (SJ) in animals resistant to pyrrolizidine alkaloid (PA) intoxication and to determine the extent of alterations in mineral metabolism as a result of SJ intoxication. Inclusion of SJ into diets containing added copper (Cu) resulted in increased (P<.01) liver...
Resource Type:: Dissertation
Full Text:: . Fractionation was carried out at 0 C as follows: Sorvall RC2-B centrifuge (SS-34 head); 1) nuclei and debris

Influence of dietary factors on tansy ragwort toxicosis in rats and horses

Creator:: Garrett, Betsy Jayne
Abstract:: Several experiments were conducted to investigate the effect of dietary factors such as amino acids, B vitamins, butylated hydroxyanisole (BHA) and phenobarbital on pyrrolizidine alkaloid toxicosis in rats and horses. The influence of St. John's wort, bracken, comfrey, and alfalfa on tansy ragwort toxicity was also examined. Effects of dietary...
Resource Type:: Masters Thesis
Full Text:: prebloom vegetative stage. The plants were dried at 45°C, finely ground in a Wiley mill, and stored at

Effects of dietary pyrrolizidine alkaloids on copper and vitamin A metabolism in the chicken and Japanese quail

Creator:: Huan, Jianya
Abstract:: Objectives of this study were to examine effects of dietary pyrrolizidine alkaloids (PA) on copper and vitamin A metabolism in the chicken which are very susceptible to the hepatoxic effects of PA and Japanese quail which are highly resistant to PA. Also, the possible interaction between copper and vitamin A...
Resource Type:: Masters Thesis

Hypervitaminosis A : effects on reproduction and interactions with pyrrolizidine alkaloids

Creator:: Moghaddam, Mehran Fallah
Abstract:: In the first experiment the minimum dietary toxic levels of vitamin A were determined in pregnant rabbits over three parities. The treatments consisted of basal diet plus 10,000, 30,000, 60,000, and 90,000 IU/Kg added vitamin A. The basal diet was formulated to be free of vitamin A and beta-carotene; rice...
Resource Type:: Masters Thesis
Full Text:: degradation of various blood particulates. c. Hepatocytes or parenchymal cells. Hepatocytes constitute the

ScholarsArchive@OSU

Dietary factors influencing the toxicity of tansy ragwort (Senecio jacobaea) in animals

Factors affecting the toxicity of Senecio jacobea to laboratory animals

Nutritional influences affecting senecio toxicity in laboratory animals

Determination of the transfer of pyrrolizidine alkaloids into goats milk by biological assay

Selenium effects and species differences in hepatic metabolism of pyrrolizidine alkaloids and other xenobiotics

Mutagenic and toxicologic implications of pyrrolizidine (Senecio) alkaloids

Senecio jacobaea : toxicity and effects on mineral metabolism in animals

Influence of dietary factors on tansy ragwort toxicosis in rats and horses

Effects of dietary pyrrolizidine alkaloids on copper and vitamin A metabolism in the chicken and Japanese quail

Hypervitaminosis A : effects on reproduction and interactions with pyrrolizidine alkaloids

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