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Filtering by: Creator DuBois, Barent Nathan Advisor Cherala, Ganesh

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Creator:

DuBois, Barent Nathan

Abstract:

Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...

Resource Type:

Dissertation

Full Text:

ABSTRACT OF THE DISSERTATION OF Barent Nathan DuBois for the degree of Doctor of Philosophy in
Effect of Perinatal Low Protein Diet on the Expression of Renal Organic Cation Transporter 2 and Novel Organic Cation Transporter 2 in Adult Rats

Creator:

Nguyen, Paulina M.

Abstract:

Studies have established that there is a greater risk for onset of adult metabolic syndrome disease such as diabetes mellitus, hypertension, hyperlipidemia, and obesity in subjects born with low birth weight (LBW). Undernourished fetuses make adaptions that result in structurally, morphologically, and functionally altered organs. In terms of drug pharmacokinetics,...

Resource Type:

Honors College Thesis

Full Text:

guide, who has been with me every step of the way. My lab colleagues, Jake Pearson and Barent