The object of this study is the synthesis of trans-cyclopentane-1, 2-dicarboxylic acid. Five procedures designed for the synthesis of
this trans diacid are described in the literature. The procedure
devised by Perkin in 1887, Fuson and Cole in 1938, and by Brenner
in 1961 were investigated to determine which of...
The reaction between 4- chloro- 6- methoxy- 5-nitropyrimidine
and methylamine was investigated. The reaction product was identified
as 4-methoxy-6-methylamino-5-nitropyrimidine from synthesis
of the product via 4-chloro-6-methylamino-5-nitropyrimidine.
The product was the result of displacement of chloro substituent with methylamine. The reaction occured under mild condition (e. g. 15-20
C. in dioxane)....
Since many 1, 4, 5, 6-tetrahydropyrimidines have become available
and commercially useful in recent years, a study of the chemistry
of certain of these compounds has been undertaken.
2-Hydroxy- and 2-mercapto-1, 4, 5, 6-tetrahydropyrimidine
have been synthesized by the condensation of urea and thiourea, respectively,
with 1, 3-propanediamine, with yields...
In recent years nuclear reduction of pyrimidines by catalytic hydrogenation in acid media has been considered a possible synthetic method for the preparation of substituted tetrahydropyrimidines. This technique has the advantage of simplicity over the older condensation methods and is limited only by the preparation of the appropriately substituted pyrimidines....