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A study of the permanganate oxidation of 4-methylpyrimidine to pyrimidine-4-carboxylic acid

Creator:: Ni, Rain Wo
Abstract:: The yields from the oxidation of 4-methylpyrimidine with potassium permanganate were found to increase from 25 to 92 percent by the addition of small amount of potassium hydroxide to the reaction mixture. Pyrimidine-4-carboxylic acid decarboxylates in hot aqueous solution to yield pyrimidine and carbon dioxide. The rate is that decarboxylation...
Resource Type:: Masters Thesis

The reaction of methylhydrazine with various 2-substituted 4,6-dimethoxy-5-nitropyrimidines

Creator:: Landberg, Björn Erik
Resource Type:: Masters Thesis

A study of certain reactions of 4-chloro-6-methylhydrazino-5-nitropyrimidine and the 4-methoxy and 6-dimethylamino analogs

Creator:: Tantivanich, Amnard
Abstract:: The reaction between 4- chloro- 6- methoxy- 5-nitropyrimidine and methylamine was investigated. The reaction product was identified as 4-methoxy-6-methylamino-5-nitropyrimidine from synthesis of the product via 4-chloro-6-methylamino-5-nitropyrimidine. The product was the result of displacement of chloro substituent with methylamine. The reaction occured under mild condition (e. g. 15-20 C. in dioxane)....
Resource Type:: Masters Thesis

The synthesis and cyclization of 2,4-diaminobutyric acid

Creator:: Li, Chun-wing
Abstract:: The objectives of this study were to isolate 2, 4-diaminobutyric acid and to attempt cyclizing the acid and its disulfonamide derivative. The original synthetic method by Adamson was followed but a modified isolation procedure for the acid was employed. Following the synthesis, the acidic solution was passed through Dowex-3 ion-exchange...
Resource Type:: Masters Thesis

The investigations of the methods for the reduction of chloropyrimidines

Creator:: Ladpli, Vimolvan
Abstract:: This thesis investigated on the dehalogenation of 2, 4- dichloropyrimidine in various different conditions. These conditions were changed by varying the solvents, the amount of catalysts and the hydrogen chloride acceptors in order to study the effects on the yields. It was found that the ether-aqueous sodium hydroxide medium with...
Resource Type:: Masters Thesis

Study of the synthesis of trans-cyclo-pentane-1,2-dicarboxylic acid

Creator:: Pozo Cisternas, Jaime
Abstract:: The object of this study is the synthesis of trans-cyclopentane-1, 2-dicarboxylic acid. Five procedures designed for the synthesis of this trans diacid are described in the literature. The procedure devised by Perkin in 1887, Fuson and Cole in 1938, and by Brenner in 1961 were investigated to determine which of...
Resource Type:: Masters Thesis

The chemistry of certain tetrahydropyrimidines

Creator:: Anderson, Donna Lee
Abstract:: Since many 1, 4, 5, 6-tetrahydropyrimidines have become available and commercially useful in recent years, a study of the chemistry of certain of these compounds has been undertaken. 2-Hydroxy- and 2-mercapto-1, 4, 5, 6-tetrahydropyrimidine have been synthesized by the condensation of urea and thiourea, respectively, with 1, 3-propanediamine, with yields...
Resource Type:: Masters Thesis

The chlorination of uric acid by phosphorus oxychloride in the presence of certain aliphatic and aromatic amine hydrochlorides

Creator:: Haase, William Alan
Abstract:: Since the use of N, N-diethylaniline hydrochloride in the chlorination of uric acid with phosphoryl chloride seems to promote the reaction, a study of the effect of other salts of nitrogenous bases in the chlorination of uric acid was undertaken. When N, N-diethylaniline hydrochloride was used in lieu of the...
Resource Type:: Masters Thesis

A method for the isolation of canavanine by ion exchange

Creator:: Fujiwara, Allan
Abstract:: In 1959 Kitagawa discovered and isolated the amino acid, canavanine. Since its discovery much interest has been centered on this amino acid because of its biological aspects; e.g. canavanine has been shown to inhibit the growth of bacteria, viruses, protozoa, and cancer cells. The occurrence of canavanine is widespread in...
Resource Type:: Masters Thesis

An investigation of the nucleophilic substitution of the chlorosubstituted pyrimidines

Creator:: Nazeeri, Makeen Ahsan
Resource Type:: Masters Thesis

ScholarsArchive@OSU

A study of the permanganate oxidation of 4-methylpyrimidine to pyrimidine-4-carboxylic acid

The reaction of methylhydrazine with various 2-substituted 4,6-dimethoxy-5-nitropyrimidines

A study of certain reactions of 4-chloro-6-methylhydrazino-5-nitropyrimidine and the 4-methoxy and 6-dimethylamino analogs

The synthesis and cyclization of 2,4-diaminobutyric acid

The investigations of the methods for the reduction of chloropyrimidines

Study of the synthesis of trans-cyclo-pentane-1,2-dicarboxylic acid

The chemistry of certain tetrahydropyrimidines

The chlorination of uric acid by phosphorus oxychloride in the presence of certain aliphatic and aromatic amine hydrochlorides

A method for the isolation of canavanine by ion exchange

An investigation of the nucleophilic substitution of the chlorosubstituted pyrimidines

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