The reaction between 4- chloro- 6- methoxy- 5-nitropyrimidine
and methylamine was investigated. The reaction product was identified
as 4-methoxy-6-methylamino-5-nitropyrimidine from synthesis
of the product via 4-chloro-6-methylamino-5-nitropyrimidine.
The product was the result of displacement of chloro substituent with methylamine. The reaction occured under mild condition (e. g. 15-20
C. in dioxane)....
The yields from the oxidation of 4-methylpyrimidine with potassium permanganate were found to increase from 25 to 92 percent by the addition of small amount of potassium hydroxide to the reaction mixture. Pyrimidine-4-carboxylic acid decarboxylates in hot aqueous solution to yield pyrimidine and carbon dioxide. The rate is that decarboxylation...
The objectives of this study were to isolate 2, 4-diaminobutyric
acid and to attempt cyclizing the acid and its disulfonamide derivative.
The original synthetic method by Adamson was followed but a
modified isolation procedure for the acid was employed.
Following the synthesis, the acidic solution was passed through
Dowex-3 ion-exchange...
This thesis investigated on the dehalogenation of 2, 4-
dichloropyrimidine in various different conditions. These conditions
were changed by varying the solvents, the amount of catalysts and
the hydrogen chloride acceptors in order to study the effects on the
yields.
It was found that the ether-aqueous sodium hydroxide medium
with...
The unique reaction between 4, 6-dimethoxy-5-nitropyrimidine
and methylhydrazine was investigated. The reaction product was
identified as 4-hydrazino-6-hydroxypyrimidine from (a) spectral
data, (b) by direct synthesis of the product via 4-chloro-6-hydroxypyrimidine
and hydrazine, and (c) by conversion of the product to
the known 4-amino-6-hydroxypyrimidine using Raney nickel. The
product was not...
Ultraviolet spectroscopic methods for the determination
of dissociation constants can only be applied to
those compounds having protonatable sites conjugated with
or inherent in a chromophoric group of the compound.
The determination of the dissociation constants of
organic nitrogeneous bases by ultraviolet spectroscopic
methods was found to be only reliable...
The object of this study is the synthesis of trans-cyclopentane-1, 2-dicarboxylic acid. Five procedures designed for the synthesis of
this trans diacid are described in the literature. The procedure
devised by Perkin in 1887, Fuson and Cole in 1938, and by Brenner
in 1961 were investigated to determine which of...
Since many 1, 4, 5, 6-tetrahydropyrimidines have become available
and commercially useful in recent years, a study of the chemistry
of certain of these compounds has been undertaken.
2-Hydroxy- and 2-mercapto-1, 4, 5, 6-tetrahydropyrimidine
have been synthesized by the condensation of urea and thiourea, respectively,
with 1, 3-propanediamine, with yields...
In 1959 Kitagawa discovered and isolated the amino acid,
canavanine. Since its discovery much interest has been centered on
this amino acid because of its biological aspects; e.g. canavanine has
been shown to inhibit the growth of bacteria, viruses, protozoa, and
cancer cells.
The occurrence of canavanine is widespread in...
Since the use of N, N-diethylaniline hydrochloride in the chlorination
of uric acid with phosphoryl chloride seems to promote the
reaction, a study of the effect of other salts of nitrogenous bases in
the chlorination of uric acid was undertaken. When N, N-diethylaniline
hydrochloride was used in lieu of the...
In recent years nuclear reduction of pyrimidines by catalytic hydrogenation in acid media has been considered a possible synthetic method for the preparation of substituted tetrahydropyrimidines. This technique has the advantage of simplicity over the older condensation methods and is limited only by the preparation of the appropriately substituted pyrimidines....
Vegetable oils have always played an essential role in the diet of man, besides being an important raw material in many industries. The demand for these oils increases with the population and through the discovery of new uses for them. In order to meet this increasing demand, oils from new,...