This thesis investigated on the dehalogenation of 2, 4-
dichloropyrimidine in various different conditions. These conditions
were changed by varying the solvents, the amount of catalysts and
the hydrogen chloride acceptors in order to study the effects on the
yields.
It was found that the ether-aqueous sodium hydroxide medium
with...
The reaction between 4- chloro- 6- methoxy- 5-nitropyrimidine
and methylamine was investigated. The reaction product was identified
as 4-methoxy-6-methylamino-5-nitropyrimidine from synthesis
of the product via 4-chloro-6-methylamino-5-nitropyrimidine.
The product was the result of displacement of chloro substituent with methylamine. The reaction occured under mild condition (e. g. 15-20
C. in dioxane)....
The unique reaction between 4, 6-dimethoxy-5-nitropyrimidine
and methylhydrazine was investigated. The reaction product was
identified as 4-hydrazino-6-hydroxypyrimidine from (a) spectral
data, (b) by direct synthesis of the product via 4-chloro-6-hydroxypyrimidine
and hydrazine, and (c) by conversion of the product to
the known 4-amino-6-hydroxypyrimidine using Raney nickel. The
product was not...