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Filtering by: Creator Grove, G. G. Advisor Crannell, Wanda License Attribution-NonCommercial-ShareAlike 4.0 (CC BY-NC-SA 4.0)

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:

Sanchez, Karina M.

Abstract:

Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...

Resource Type:

Undergraduate Thesis

Full Text:

ingested 1000mg of APAP Subject Ht (cm) Wt (kg) BMI Age T0 urine (g) T8 urine (g) AVC001 177 69.2 22.1