Index Catalog // ScholarsArchive@OSU

Developmental axial skeletal deformities : baseline study with a zebrafish model

Creator:: Harden, Jon M.
Abstract:: The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Resource Type:: Masters Thesis
Full Text:: Deformities: Baseline Study with a Zebrafish Model. Abstract approved Lawrence R. Curtis The aim of this

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Creator:: Barnhill, Melanie L.
Abstract:: Feeding rainbow trout 0.3-0.4 mg dieldrinlkg/d for 9-12 weeks stimulated the biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500% and [³H]7,12- dimethylbenz[a]anthracene (DMBA) by 240%. In vitro work demonstrated that this interaction occurred without induction of the cytochrome P450 system, or other hepatocellular proteins involved in metabolism. The...
Resource Type:: Masters Thesis
Full Text:: . Curtis, who provided continued guidance and valuable support during my graduate studies, while also

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: like to express my deepest appreciation and gratitude to my advisor, Dr. Lawrence R. Curtis for his

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: ): Lawrence Curtis, Mary Arkoosh, William Baird, Nancy Kerkvliet, Gary DeLander and Tracy Collier for taking

Water quality modulation of aluminum toxicity to rainbow trout (Oncorhynchus mykiss) : biological and physiological approaches

Creator:: Gundersen, Deke T.
Resource Type:: Dissertation
Full Text:: mykiss): Biological and Physiological Approaches. Abstract approved: Lawrence R. Curtis Aluminum

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: Aromatic Hydrocarbon Mixture Abstract approved: Lawrence R. Curtis Polycyclic aromatic hydrocarbons

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: . Lawrence R. Curtis Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair

Temperature modulated aflatoxin B1 hepatic disposition, and formation and persistence of DNA adducts in rainbow trout

Creator:: Zhang, Quan, 1957-
Resource Type:: Masters Thesis
Full Text:: Persistence of DNA Adducts in Rainbow Trout. Abstract approved:_ Redacted for Privacy Lawrence R. Curtis

Mechanisms affecting the bioaccumulation of dietary quinoline by rainbow trout (Salmo gairdneri)

Creator:: Dauble, Dennis D.
Abstract:: Factors that influenced the uptake, storage, and elimination of dietary quinoline by rainbow trout (Salmo gairdneri) were studied to obtain an understanding of the mechanisms affecting the bioaccumulation of dietary contaminants in teleosts. Rainbow trout readily absorbed ¹⁴C-quinoline from pelleted food (1% ration at 138 ug quinoline/g food) and most...
Resource Type:: Dissertation
Full Text:: Lawrence R. Curtis Factors that influenced the uptake, storage, and elimination of dietary quinoline by

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: . Curtis Chlordecone belongs to the class of persistent organochlorine pesticides that are

ScholarsArchive@OSU

Developmental axial skeletal deformities : baseline study with a zebrafish model

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Water quality modulation of aluminum toxicity to rainbow trout (Oncorhynchus mykiss) : biological and physiological approaches

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Temperature modulated aflatoxin B1 hepatic disposition, and formation and persistence of DNA adducts in rainbow trout

Mechanisms affecting the bioaccumulation of dietary quinoline by rainbow trout (Salmo gairdneri)

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

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