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Filtering by: Creator Downes, Sharon Advisor Curtis, Lawrence R. Subject Chlordecone -- Toxicology

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:

Lee, Junga

Abstract:

Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...

Resource Type:

Dissertation

Full Text:

. Sharon Kruger, Dr. Yu Zhen Marilyn Henderson and Beth Siddens for their help and friendship. Also