Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage.
The aim of this study...
Two Oregon reservoirs contaminated by different mercury
sources were compared for mercury distribution in sediment and
bioaccumulation by fish. The average mercury concentration in
the sediment of Cottage Grove reservoir (0.67 ± 0.05 μg/g dry
wt) was higher than for Dorena Reservoir (0.12 ± 0.01 μg/g dry
wt). Sediment mercury...
Temperature influences the incidence of chemically induced cancer in fish,
with warmer temperatures being associated with higher cancer incidence. The
mechanisms of temperature-modulated chemical carcinogenesis in fish, however,
have not been described in detail. Therefore, one primary objective of this study
was increased understanding of how temperature-modulated genotoxicity of 7,12-...
Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Female mink (Mustela vison) are highly sensitive to polychlorinated biphenyl (PCB)-induced reproductive impairment. The goal of this research was to develop a better understanding of the mechanism of PCB-induced effects on female mink, mink embryos, and surviving mink kits. Anestrous, juvenile female mink and pregnant, adult mink were exposed to...
Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis
in mice and rats. To increase understanding of how chlordecone (CD), an OC
insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD
pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...