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Filtering by: Committee Member Karplus, Andy Remove constraint Committee Member: Karplus, Andy Advisor Dashwood, Rod Remove constraint Advisor: Dashwood, Rod

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  • Dietary organosulfur and organoselenium compounds as HDAC inhibitors

    Creator:
    Nian, Hui
    Abstract:
    Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
    Resource Type:
    Dissertation