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Filtering by: Creator Kawula, Steven P. Advisor Dolan, Brian Degree Level Bachelor's

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

Creator:

VanderHoek, Eden N.

Abstract:

Human epidermal growth factor receptor 2 (HER2), a member of the receptor tyrosine kinase (RTK) family, is frequently dysregulated in a variety of cancers. Overexpression of the receptor leads to increased cell proliferation and resistance to cell death due to downstream signaling effects. Proteasomal degradation of HER2 results in the...

Resource Type:

Honors College Thesis

Full Text:

independent experiments. * P<0.01 Figure 3: Removing of Existing Peptide-MHC I Complexes Increases
Cytokine expression in Danio rerio (zebrafish) in response to TLR-7 agonist - Imiquimod

Creator:

Paternostro, Kevin Alan

Abstract:

Utilizing Danio rerio (zebrafish) as a model organism has gained popularity recently, however a lack of research into their immune response pathways had led to the discovery of subclinical infections, and has potentially confounded results. We conducted a study to determine the cytokine expression from TLR activation in order to...

Resource Type:

Honors College Thesis

Full Text:

with the visible effects of P. neurophilia, many sub-clinical infections have also been