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Filtering by: Committee Member Braunworth, Bill Advisor Dreher, Theo W.

Translation of dengue virus RNA : influence of the untranslated regions on 5´-cap dependent translation and ribosome scanning

Creator:

Chiu, Wei-Wei

Abstract:

In this thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero cells. The dengue reporter mRNA construct, which harbors 5´-terminal viral nts and 3´-terminal nts, could be translated efficiently compared to an alpha globin reporter construct. The 5´-cap structure and 3´-untranslated region...

Resource Type:

Dissertation

Full Text:

to Dr. George Rohrmann, Dr. Valerian Dolja, Dr. Walt Ream, Dr. Bill Braunworth and Dr. Rhian Cope