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Filtering by: Creator Wong, Carmen P. Advisor Filtz, Theresa M. Resource Type Honors College Thesis

Regulation by a developmental transcription factor of signaling enzymes related to atrial fibrillation

Creator:

Law, Christina M.

Abstract:

Atrial fibrillation is the most common cardiac arrhythmia, and the mechanisms that lead to this heart defect are not fully understood. Consequently, treatments for this defect do not currently reverse structural or molecular variations that lead to cardiac arrhythmia. Loss of the gene coding for the transcription factor Pitx2 leads...

Resource Type:

Honors College Thesis

Full Text:

genial demeanor and for his help with Western blots. I would also like to thank Xuemei Wong and Chih
Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Creator:

Nagra, Alamjit K.

Abstract:

Immature T cells, known as thymocytes, undergo development through successive stages in the thymus and the periphery to become functional mature T cells. These stages are regulated by sequence specific transcription factors (SSTFs). Two such SSTFs, BCL11B and TCF-1, are both known master regulators of thymopoiesis, which is also known...

Resource Type:

Honors College Thesis

Full Text:

development of Natural Killer-like cells and down-regulation of T cell genes such as tcrβ and cd3 (P. Li et