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Filtering by: Creator Berstein, R. Advisor Filtz, Theresa M.

Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts

Creator:

Kwon, Sun Hyung

Abstract:

The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...

Resource Type:

Masters Thesis
Regulation of phospholipase C-beta isozymes by calmodulin

Creator:

McCullar, Jennifer Star

Abstract:

Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well characterized, but little is known about other protein interactions that may also regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library with...

Resource Type:

Dissertation