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Filtering by: Creator Mellbye, Brett Advisor Geller, Bruce

Gene-specific antibiotic development: Evaluating effectiveness and investigating antibiotic-resistant Escherichia coli mutants of phosphorodiamidate morpholino oligomers

Creator:

Puckett, Susan E.

Abstract:

Phosphorodiamidate morpholino oligomers (PMOs) are novel antisense drugs in the early stages of development. These synthetic DNA mimics contain the same bases found in DNA and anneal to RNA in a complementary fashion. PMOs have been designed that target genes responsible for producing essential proteins in organisms such as Escherichia...

Resource Type:

Honors College Thesis

Full Text:

project, answering all of my questions, and helping me with my thesis. Finally, thank you Brett Mellbye
Antisense Antibiotics

Creator:

Mitev, Georgi Mitko

Abstract:

Two different types of Phosphorodiamidate Morpholino Oligomers (PMOs) were used to inhibit growth in pure cultures of Salmonella enterica serovar typhimurium and in mouse macrophages infected with S. typhimurium. Both PMOs were 11 bases long and complementary to bases 6-16 of acyl carrier protein mRNA. A membrane-penetrating peptide, (RXR)4XB, was...

Resource Type:

Honors College Thesis

Full Text:

her excellent guidance, Brett Mellbye for assistance with my project, Shannon Oda for teaching me