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Filtering by: Alternative title ssim EC 743 Remove constraint Alternative title ssim: EC 743 Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H. Committee Member Proteau, Philip Remove constraint Committee Member: Proteau, Philip

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  • New bioactive natural products from marine algae and cyanobacteria

    Creator:
    Sabry, Omar Mohamed
    Abstract:
    This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
    Resource Type:
    Dissertation
    Full Text:
    agent that is currently in phase Ill clinical trial is ecteinascidin 743 (11 ),22 isolated from the

  • Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

    Creator:
    Han, Bingnan
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
    Resource Type:
    Dissertation
    Full Text:
    anticancer natural products are ecteinascidin 743 (10) and bryostatin 1 (11) (Tablel. I). The marine

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    Doublet DHiv Dihydroxyisovaleric acid DMSO Dimethylsulfoxide EC Effective Concentration EtOAc Ethyl