Index Catalog // ScholarsArchive@OSU

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: polyketide nature and established a new example of a general trend in cyanobacterial metabolism where both S

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

Creator:: Ramaswamy, Aishwarya V.
Abstract:: Cyanobacteria are rich in biologically active secondary metabolites, many of which have potential application as anticancer or antimicrobial drugs or as useful probes in cell biology studies. A Jamaican isolate of the marine cyanobacterium, Lyngbya majuscula was the source of a novel antifungal and cytotoxic secondary metabolite, hectochlorin. The structure...
Resource Type:: Dissertation
Full Text:: -polymerase chain reaction SAM S-adenosyl methionine SDS Sodium dodecyl sulphate TE Thioesterase VLC

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

Creator:: Jiang, Zhi-dong
Resource Type:: Dissertation
Full Text:: galactolipids and two novel pyrroles. The major oxylipin, 12(R), I 3(S)-diHEPE, is an inhibitor of progesterone

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: Temperature s Singlet SCUBA Self-Contained Underwater Breathing Apparatus t Triplet TOCSY Total

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: University provided the four stereoisomers of antillatoxin. Dr. Philip S. Magee of the BioSAR Research

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: Infrared Spectroscopy LD Lethal Dose LT Leukotriene LX Lipoxin LO Lipoxygenase M S Mass

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: - linolenates, It was determined that the enzyme intramolecularly transfers the bis- allylic pro-S-hydrogen

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: with S-[methyl-13Cjmethionine. 148 Vl.8 13C NMR spectra of A) jamaicamide A isolated from cultures

Bioactive natural products from marine algae

Creator:: Tan, Lik Tong
Abstract:: This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
Resource Type:: Dissertation
Full Text:: Exchange Spectroscopy RT Room Temperature s Singlet SCUBA Self-Contained Underwater Breathing Apparatus

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: by Drs. Proteau and Gerwick. Robin S. Geralds prepared of the methoxy-methyl ketone derivative of

ScholarsArchive@OSU

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

New bioactive natural products from marine algae and cyanobacteria

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Bioactive natural products from marine algae

Novel oxylipins and other bioactive metabolites from marine algae

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