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Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Brian L. Marguez for the degree of

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: deaply rewarding experience. I should like to thank the members of my graduate committee, Drs. Gary E

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

Creator:: Jiang, Zhi-dong
Resource Type:: Dissertation
Full Text:: on 12(S)-HPE I E. The three galactolipids are the first example of MGDAG and DGDAG with specifically

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: , lyngbyabellins E-1, along with the known compound dolabellin, originally isolated from sea hare Dolabella

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Creator:: Milligan, Kenneth Edward
Abstract:: This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
Resource Type:: Dissertation
Full Text:: . (c)copynght by Kenneth E. Milhigan III October 10, 2001 All Rights Reserved MARINE ALGAL

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: , representing Pharmacy Dean of the College of Pharmacy Dean of Grad e School I understand that my thesis will

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: throughout my graduate career at Oregon State University. I would also like to acknowledge Brian Arbogast

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: guidance throughout my graduate career at Oregon State University. I would also like to acknowledge Brian

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:: Sitachitta, Namthip
Abstract:: The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
Resource Type:: Dissertation
Full Text:: would like to acknowledge Rodger Kohnert for his assistance with NMR experiments, and Brian Arbogast

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

Creator:: Williamson, R. Thomas
Resource Type:: Dissertation
Full Text:: . Carney. I would like to thank Brian L. Marquez for many interesting conversations and also for being a

ScholarsArchive@OSU

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Novel oxylipins and other bioactive metabolites from marine algae

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

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