Index Catalog // ScholarsArchive@OSU

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Brian L. Marguez for the degree of

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: guidance throughout my graduate career at Oregon State University. I would also like to acknowledge Brian

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: heteronuclear multiple-bond coherence spectroscopy (HMBC) and 2-D nuclear Overhauser exchange spectroscopy

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:: Sitachitta, Namthip
Abstract:: The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
Resource Type:: Dissertation
Full Text:: described cytotoxins, curacins A and D. Upon further investigation of the same extract, two new

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Creator:: Milligan, Kenneth Edward
Abstract:: This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
Resource Type:: Dissertation
Full Text:: Chemistry NMR), Brian Arborgast (Dept. of Chemistry EIHMS), and the laboratory of Dr. Victor Hsu (600 MHz

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: helpful discussions; Brian Arbogast for his mass spectral work; Roger Kohnert for NMR spectroscopy. I

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: to Jeff More and Brian Arbogast (Department of Chemistry, OSU) for their extensive mass spectral

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Creator:: Proteau, Philip J.
Resource Type:: Dissertation
Full Text:: and Brian Arbogast for providing mass spectra, and Jeannine Lawrence and Dr. Curt Johnson for CD

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: , residues rarely observed in marine cyanobacterial metabolites. Extensive utilization of 1 D and 2D NMR

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

Creator:: Jiang, Zhi-dong
Resource Type:: Dissertation
Full Text:: cyclo-ID-PHE-D-LEU-L-ILE-D- allo-ILE-L-LEU-GLY-D-BAOA-L-HSER-DHHA-L-HYPRO-L-HSERI structure. Novel

ScholarsArchive@OSU

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Novel oxylipins and other bioactive metabolites from marine algae

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

New bioactive natural products from marine algae and cyanobacteria

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

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