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Filtering by: Creator Muñoz, P. Remove constraint Creator: Muñoz, P. Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

    Creator:
    Milligan, Kenneth Edward
    Abstract:
    This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
    Resource Type:
    Dissertation
    Full Text:
    further chemical investigations of P. homemanni. A total of six related polyhalogenated monoterpenes were

  • Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

    Creator:
    Han, Bingnan
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
    Resource Type:
    Dissertation

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    transcriptional factor NF-Y to its target sequence on the MDR1 gene which encodes for a P- glycoprotein-mediated

  • Bioactive natural products from marine algae

    Creator:
    Tan, Lik Tong
    Abstract:
    This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
    Resource Type:
    Dissertation

  • Natural products from tropical and temperate marine algae

    Creator:
    Bernart, Matthew W.
    Abstract:
    Following surveys of seaweeds in Oregon and the Caribbean, four algal species were selected for study on the basis of their crude extract biological activity or thin-layer chromatographic characteristics. Extracts were fractionated by normal phase chromatography, including high performance liquid chromatography (HPLC). Derivatives (methyl esters, acetates, and benzoates) of natural...
    Resource Type:
    Dissertation
    Full Text:
    , especially during times when I was encountering misfortune in and away from the laboratory. Dr. Kevin P

  • Natural products studies of the marine cyanobacterium Lyngbya majuscula

    Creator:
    Sitachitta, Namthip
    Abstract:
    The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
    Resource Type:
    Dissertation