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Filtering by: Alternative title ssim EC 1225 Remove constraint Alternative title ssim: EC 1225 Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Novel oxylipins and other bioactive metabolites from marine algae

    Creator:
    Nagle, Dale George
    Abstract:
    I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
    Resource Type:
    Dissertation
    Full Text:
    DMSO Dimethylsulfoxide EC Effective Concentration EI Electron Impact EtOAc Ethyl Acetate FAB Fast

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    Doublet DHiv Dihydroxyisovaleric acid DMSO Dimethylsulfoxide EC Effective Concentration EtOAc Ethyl