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Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:: Sitachitta, Namthip
Abstract:: The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
Resource Type:: Dissertation
Full Text:: presence ofa monosubstituted phenyl moiety [o 139.01 (s), 128.61 (2C, d), 128.73 (2C, d), 126.48 (1C, d

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: Infrared Spectroscopy LD Lethal Dose LT Leukotriene LX Lipoxin LO Lipoxygenase M S Mass

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: Temperature s Singlet SCUBA Self-Contained Underwater Breathing Apparatus t Triplet TOCSY Total

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: University provided the four stereoisomers of antillatoxin. Dr. Philip S. Magee of the BioSAR Research

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: COSY, HMBC, and NOE correlations for 1 ........................................117 V.7 '5 (s-R) values

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

Creator:: Williamson, R. Thomas
Resource Type:: Dissertation
Full Text:: [S-methyl '3C] methionine feeding 35 experiment. 11.9. Biosynthesis of tryptophan from primary

Natural products from tropical and temperate marine algae

Creator:: Bernart, Matthew W.
Abstract:: Following surveys of seaweeds in Oregon and the Caribbean, four algal species were selected for study on the basis of their crude extract biological activity or thin-layer chromatographic characteristics. Extracts were fractionated by normal phase chromatography, including high performance liquid chromatography (HPLC). Derivatives (methyl esters, acetates, and benzoates) of natural...
Resource Type:: Dissertation
Full Text:: encompassing term for PUFA metabolites formed by reaction(s) involving one or more steps of mono- or di

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: by Drs. Proteau and Gerwick. Robin S. Geralds prepared of the methoxy-methyl ketone derivative of

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Creator:: Proteau, Philip J.
Resource Type:: Dissertation
Full Text:: light irradiance. Although its existence was known since the mid 1800's, the structure of this pigment

Novel icosanoids from the red marine alga Farlowia mollis

Creator:: Solem, Michele Lee
Abstract:: Farlowia mollis is a marine red alga that grows in the intertidal region along the coast of Oregon. We began studying the chemistry of this alga after a survey of Oregon seaweeds revealed possibly interesting chemistry and antimicrobial activity in its crude organic extract. Over the past three years the...
Resource Type:: Masters Thesis
Full Text:: goiter, scrofula and dropsy for more than 20 centuries.22 Not until the 1950's did western societies

ScholarsArchive@OSU

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

New bioactive natural products from marine algae and cyanobacteria

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

Natural products from tropical and temperate marine algae

Novel oxylipins and other bioactive metabolites from marine algae

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Novel icosanoids from the red marine alga Farlowia mollis

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