Index Catalog // ScholarsArchive@OSU

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: . De Lander, T. Mark Zabriskie, Thomas F. Savage, and George H. Constantine for their valuable

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: evaluation of curacin A (13).66,67 25 CH3 CH3 0 o;;;-------o OH T Q 4cH3 T 0 CH3 8H3

Natural products from temperate and tropical marine algae

Creator:: Graber, Melodie A.
Resource Type:: Masters Thesis
Full Text:: I OH N+ -*Nli-t %H NH N11.....+4)-LN NH H >=N+ w \ OH NH I H OH0 -....s .0 10 11

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: -, monohydrochloride t Triplet TEA Trifluoroacetic acid TOCSY Total Correlation Spectroscopy tR Retention Time Tyr

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Creator:: Proteau, Philip J.
Resource Type:: Dissertation
Full Text:: 174.22 - - 2 33.93 2.32, t (7.5) 2.30, t (7.5) 33.93 2.32, t (7.6) 3 24.53 1.65, tt (7.8, 7.5) 1.62

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Creator:: Milligan, Kenneth Edward
Abstract:: This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
Resource Type:: Dissertation
Full Text:: chromatography RT Room temperature s Singlet SPE Solid phase extraction t Triplet TLC Thin layer

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: from the C11 position to the C13 position. Furthermore, the bis-allylic pro-R-hydrogen at C8 in T

Biosynthetic investigations of two secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Creator:: Rossi, James V.
Abstract:: Marine cyanobacteria have been shown to produce a variety of biologically active and stucturally diverse secondary metabolites. These compounds are of interest to natural products researchers mainly because of their potential application as biomedicinals, biochemical probes, and agrichemicals. The metabolic pathways utilized by the cyanobacterium Lyngbya majuscula to generate curacin...
Resource Type:: Masters Thesis
Full Text:: -Packard model 5890 series II connected to a Hewlett-Packard model 5971 mass spectrometer). Total ion and

Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Creator:: Wu, Min, 1963-
Abstract:: Marine algae have been recognized as a rich resource of new and unusual organic molecules with diverse biological properties. The current need to develop new antifungal, anticancer, antibiotic and antiviral drugs has led to an intense research effort into the discovery, isolation and structure determination of potential medicinal agents from...
Resource Type:: Masters Thesis
Full Text:: 14 Tetradotoxin 15 Saxitodn 16 Okadaic acid Me OH H Me **OH s 0 i H . O % H H H .t. 0 oo 8

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:: Sitachitta, Namthip
Abstract:: The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
Resource Type:: Dissertation
Full Text:: for providing mass spectral data. I am grateful to Dr. T. Murray (U. of Georgia) for performing the

ScholarsArchive@OSU

Novel oxylipins and other bioactive metabolites from marine algae

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Natural products from temperate and tropical marine algae

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Biosynthetic investigations of two secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Natural products studies of the marine cyanobacterium Lyngbya majuscula

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