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Filtering by: Creator Putnam, Nathan F. Remove constraint Creator: Putnam, Nathan F. Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Novel oxylipins and other bioactive metabolites from marine algae

    Creator:
    Nagle, Dale George
    Abstract:
    I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
    Resource Type:
    Dissertation
    Full Text:
    . De Lander, T. Mark Zabriskie, Thomas F. Savage, and George H. Constantine for their valuable

  • Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

    Creator:
    Han, Bingnan
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
    Resource Type:
    Dissertation
    Full Text:
    (B series) of lyngbyabellin E (1) .................94 IV.7 1H and 13C spectra of lyngbyabellin F (2

  • Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

    Creator:
    Wu, Min, 1963-
    Abstract:
    Marine algae have been recognized as a rich resource of new and unusual organic molecules with diverse biological properties. The current need to develop new antifungal, anticancer, antibiotic and antiviral drugs has led to an intense research effort into the discovery, isolation and structure determination of potential medicinal agents from...
    Resource Type:
    Masters Thesis
    Full Text:
    Lyngbya majuscula (4.32g) Gradient Vacuum Chromatography EtOAc / Hexane 4%-100% I I I-1 D E F G (420 mg

  • Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

    Creator:
    Vulpanovici, Florina Alexandra
    Abstract:
    This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
    Resource Type:
    Dissertation
    Full Text:
    , including kahalalide F (Hamann et al., 1996). Currently undergoing preclinical evaluation, kahalalide F (16

  • Novel secondary metabolites from a Madagascar collection of Lyngbya majuscula

    Creator:
    Nannini, Christopher J.
    Abstract:
    Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
    Resource Type:
    Masters Thesis
    Full Text:
    (15) OCH 0 H3C(H2C)6AN OR H Malyngamide F (11) R= H Malyngamide F Acetate (12) R = Ac OCH 0 0

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    Phthalascidin (10) F!] The sea hare Dolabella auricularia, an herbivorous mollusc from the Indian Ocean

  • Natural products studies of the marine cyanobacterium Lyngbya majuscula

    Creator:
    Sitachitta, Namthip
    Abstract:
    The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
    Resource Type:
    Dissertation
    Full Text:
    MALYNGAMIDE F ACETATE, MALYNGAMIDES H, I, K AND INDOLE DERIVATIVES FROM THE MARINE CYANOBACTERIUM LYNGBYA

  • New bioactive natural products from marine algae and cyanobacteria

    Creator:
    Sabry, Omar Mohamed
    Abstract:
    This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
    Resource Type:
    Dissertation
    Full Text:
    cyanobacterium, Lyngbya majuscula;36 kahalalide F (22) from the Hawaiian mollusk, Elysia rufescens37 and the

  • Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

    Creator:
    Milligan, Kenneth Edward
    Abstract:
    This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
    Resource Type:
    Dissertation
    Full Text:
    . HSQMBC correlations for malyngamide R (71), 144 F (76), and I (78), confirming the geometry of the vinyl

  • Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

    Creator:
    Williamson, R. Thomas
    Resource Type:
    Dissertation
    Full Text:
    gradient strengths. VIII. 1. J-IIMPEACH-MBC pulse sequence. 148 VIH.2. f-resolved HMBC-1 pulse sequence