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Filtering by: Creator Sowers, Todd A. Remove constraint Creator: Sowers, Todd A. Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Natural products from temperate and tropical marine algae

    Creator:
    Graber, Melodie A.
    Resource Type:
    Masters Thesis
    Full Text:
    . AN ABSTRACT OF THE THESIS OF Melodie A. Graber for the degree of Master of Science in Pharmacy

  • Novel secondary metabolites from a Madagascar collection of Lyngbya majuscula

    Creator:
    Nannini, Christopher J.
    Abstract:
    Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
    Resource Type:
    Masters Thesis
    Full Text:
    from a Madagascar Collection of Lyngbya ma/uscula. Abstract approved William H. Gerwick Marine

  • Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae

    Creator:
    Proteau, Philip J.
    Resource Type:
    Dissertation
    Full Text:
    Oxylipins from temperate marine algae and a photoprotective

  • Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

    Creator:
    Yoo, Hye-Dong
    Abstract:
    My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
    Resource Type:
    Dissertation
    Full Text:
    antimitotic metabolites, curacins B and C, were isolated from a Curacao collection of Lyngbya majuscula. In

  • Natural products studies of the marine cyanobacterium Lyngbya majuscula

    Creator:
    Sitachitta, Namthip
    Abstract:
    The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
    Resource Type:
    Dissertation
    Full Text:
    , curacin A and barbamide. The chemical studies with a Grenada collection ofL. majuscula revealed three

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage collected in

  • Novel oxylipins and other bioactive metabolites from marine algae

    Creator:
    Nagle, Dale George
    Abstract:
    I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
    Resource Type:
    Dissertation
    Full Text:
    Bioactive Metabolites From Marine Algae Abstract approved: William H. Gerwick I have participated in a

  • Bioactive natural products from marine algae

    Creator:
    Tan, Lik Tong
    Abstract:
    This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
    Resource Type:
    Dissertation
    Full Text:
    spongiosum Zanardini. These are a pair of stable conformers differing only in the conformation of two

  • The natural products chemistry of the red algae Ptilota filicina and Laurencia obtusa

    Creator:
    Lopez, Albert
    Abstract:
    The sea offers a wide variety of potentially useful resources. Marine algae have been a rich source of structurally unique natural products showing diverse biological properties. The current need to develop new antifungal, antibiotic, anticancer and antiviral drugs has prompted intense research efforts into the discovery, isolation and structure determination...
    Resource Type:
    Masters Thesis
    Full Text:
    The sea offers a wide variety of potentially useful resources. Marine algae have been a rich source

  • New bioactive natural products from marine algae and cyanobacteria

    Creator:
    Sabry, Omar Mohamed
    Abstract:
    This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
    Resource Type:
    Dissertation
    Full Text:
    flabellinol exhibited strong sodium channel blocking activity (EC50 = 0.3 and 0.9 pg/mI, respectively). As a