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Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Brian L. Marguez for the degree of

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Creator:: Milligan, Kenneth Edward
Abstract:: This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
Resource Type:: Dissertation
Full Text:: further chemical investigations of P. homemanni. A total of six related polyhalogenated monoterpenes were

Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Creator:: Wu, Min, 1963-
Abstract:: Marine algae have been recognized as a rich resource of new and unusual organic molecules with diverse biological properties. The current need to develop new antifungal, anticancer, antibiotic and antiviral drugs has led to an intense research effort into the discovery, isolation and structure determination of potential medicinal agents from...
Resource Type:: Masters Thesis
Full Text:: people for their technical assistance in my graduate research: Brian Arbogast for his providing the

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Creator:: Yoo, Hye-Dong
Abstract:: My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
Resource Type:: Dissertation
Full Text:: helpful discussions; Brian Arbogast for his mass spectral work; Roger Kohnert for NMR spectroscopy. I

Natural products from temperate and tropical marine algae

Creator:: Graber, Melodie A.
Resource Type:: Masters Thesis
Full Text:: individuals for their invaluable technical support during my studies: Brian Arbogast and Don Griffin for

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: throughout my graduate career at Oregon State University. I would also like to acknowledge Brian Arbogast

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: guidance throughout my graduate career at Oregon State University. I would also like to acknowledge Brian

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: to Jeff More and Brian Arbogast (Department of Chemistry, OSU) for their extensive mass spectral

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

Creator:: Williamson, R. Thomas
Resource Type:: Dissertation
Full Text:: . Carney. I would like to thank Brian L. Marquez for many interesting conversations and also for being a

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: Department of Chemistry for his assistance in NMR experiments; Brian Arbogast and Don Griffin for their

ScholarsArchive@OSU

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

Natural products from temperate and tropical marine algae

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

New bioactive natural products from marine algae and cyanobacteria

Development and application of NMR spectroscopy to marine natural products structure and biosynthesis

Novel oxylipins and other bioactive metabolites from marine algae

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