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Filtering by: Committee Member Zabriskie, Mark T. Remove constraint Committee Member: Zabriskie, Mark T. Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Novel oxylipins and other bioactive metabolites from marine algae

    Creator:
    Nagle, Dale George
    Abstract:
    I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
    Resource Type:
    Dissertation
    Full Text:
    . De Lander, T. Mark Zabriskie, Thomas F. Savage, and George H. Constantine for their valuable

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    the new ct-pyrone malyngamide T. A collection of L. majuscula from Antany Mora, Madagascar, led to

  • Novel secondary metabolites from a Madagascar collection of Lyngbya majuscula

    Creator:
    Nannini, Christopher J.
    Abstract:
    Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
    Resource Type:
    Masters Thesis
    Full Text:
    Oregon State University. I graciously thank the members of my graduate committee, Dr. Mark Zabriskie

  • Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

    Creator:
    Ramaswamy, Aishwarya V.
    Abstract:
    Cyanobacteria are rich in biologically active secondary metabolites, many of which have potential application as anticancer or antimicrobial drugs or as useful probes in cell biology studies. A Jamaican isolate of the marine cyanobacterium, Lyngbya majuscula was the source of a novel antifungal and cytotoxic secondary metabolite, hectochlorin. The structure...
    Resource Type:
    Dissertation
    Full Text:
    throughout the course of my graduate work. I would also like to thank my committee members, Dr. Mark