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Filtering by: Creator McVicker, Eileen O'Keeffe Remove constraint Creator: McVicker, Eileen O'Keeffe Advisor Giebultowicz, Jadwiga M. Remove constraint Advisor: Giebultowicz, Jadwiga M.

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  • The Effects of the Immunity Factor Relish on Aging Phenotypes in Drosophila melanogaster

    Creator:
    Kumar, Nandita
    Abstract:
    Aging is a complex biological phenomenon that alters many different physiological processes. Although many age-related phenotypes, such as neurodegeneration, weakening circadian rhythms, and inflammaging, are well-studied, the links between them are not. To elucidate these links we created an inflammation-like state in Drosophila melanogaster by overexpressing Relish (Rel), an NFκB...
    Resource Type:
    Honors College Thesis
    Full Text:
    for giving me this opportunity. Next, I would like to express my utmost gratitude to Eileen

  • Effects of Oxidative Stress on Circadian Gene Expression during Aging

    Creator:
    Bonar, Tara
    Abstract:
    All organisms possess circadian clocks, which generate daily oscillations in clock controlled gene expression that regulate many essential biological functions in synchrony with the 24-hour light/dark cycles. When the genes that control the internal clock are weakened, accelerated aging symptoms are observed. Past research in Drosophila demonstrated that aging flies...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Next I would like to thank Eileen Chow, but I am not certain that words would suffice. As an

  • Exploring functional links between circadian clocks, neurodegeneration, and aging in Drosophila melanogaster

    Creator:
    Rakshit, Kuntol
    Abstract:
    Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
    Resource Type:
    Dissertation
    Full Text:
    his expertise in biochemistry and molecular biology. I express sincere appreciation for Eileen S

  • Oxidative Stress Response Genes: A Circadian Connection?

    Creator:
    McAllister, Marisa C.
    Abstract:
    Circadian clocks are internal mechanisms regulating many physiological processes. Research suggests that the circadian clock may regulate repair of cellular damage caused by reactive oxygen species (ROS), but molecular pathways from the clock to ROS repair are not known. The gene cncC, known in mammals as Nrf2, and its repressor...
    Resource Type:
    Honors College Thesis
    Full Text:
    , and Megan Mathes throughout my year spent in the lab. Thank you to Katherine Sherman and Eileen

  • Investigating connections between the circadian system and aging in Drosophila melanogaster

    Creator:
    Long, Dani M.
    Abstract:
    Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
    Resource Type:
    Dissertation
    Full Text:
    untold amount of diet and dishes I have used over the years. A special thanks to Eileen Chow and

  • Exploring Links between Circadian Rhythms and Healthy Aging

    Creator:
    Mattison, Braden J.
    Abstract:
    Circadian rhythms are the daily oscillations in multiple organism functions, from clock gene expression to behavior. Lost or irregular rhythms lead to health problems later in life including nervous system disorders, abnormal sleep/activity cycles, diabetes and obesity. However, it is not known whether strengthening the expression of clock genes throughout...
    Resource Type:
    Honors College Thesis
    Full Text:
    thank Eileen Chow. From the first day I was in the lab, Eileen’s organization and desire to help new