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Filtering by: Alternative title ssim 4-H 1541 Remove constraint Alternative title ssim: 4-H 1541 Advisor Gould, Steven J. Remove constraint Advisor: Gould, Steven J. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Studies on the biosynthesis of the streptolidine moiety of streptothricin F

    Creator:
    Wityak, John
    Abstract:
    The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
    Resource Type:
    Dissertation
    Full Text:
    1 167.29 s H-3 4.12 1H dd 13.6, < 1 2 51.80 d H-4 4.76 1 H bs 3 58.34 d H-5-pro-S 3.85 1 H dd 14.6

  • Studies on advanced intermediates in the biosynthesis of streptonigrin

    Creator:
    Erickson, W. Randal
    Abstract:
    Early studies on the biosynthesis of the quinoline quinone portion of streptonigrin, 1, had suggested the intermediacy of novel aromatic amino acids. In order to test this hypothesis, a series of compounds was synthesized and tested for potential incorporation. [4-¹⁵N] 4-Aminoanthranilic acid, 4 5 a , [4-² H] 7-aminoquinaldinic acid,...
    Resource Type:
    Dissertation
    Full Text:
    for potential incorporation. [4-15N] 4-Aminoanthranilic acid, 4 5 a , [4-2 H] 7-aminoquinaldinic acid

  • LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

    Creator:
    Shen, Ben
    Resource Type:
    Dissertation
    Full Text:
    (P)H + 02 Yr CO2H NAD(P)+ + H20 48 Scheme 8. Enzymatic Formation of 48 form 4 7 It would be

  • Studies of the biosynthesis of Sarubicin A

    Creator:
    Eisenberg, Rodney L.
    Abstract:
    Early studies on the biosynthesis of Sarubicin A, 1, had suggested the intermediacy of the novel aromatic amino acid 6-hydroxyanthranilic acid, 17. To investigate the biosynthetic steps beyond 17, [¹³C-¹⁵N carboxamide] 6-hydroxyanthranilamide, 27a, was synthesized, and fed to fermentations of Streptomyces helicus. Incorporation of 27a into 1 provided suggestive evidence...
    Resource Type:
    Dissertation
    Full Text:
    1 m 8.0, 4.5, 1.8 4 178.8a s H-10 3.61 1 q 6.0 4a 135.211 s H-11 0.97 3 d 6.0 5 78.3 s CONH2 8.68 1