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Metabolism of L-α-arginine in the biosynthesis of blasticidin S

Creator:: Woo, Nam-tae
Abstract:: Two labelled arginines, DL-[2,3,3,-²H₃]arginine, 8, and DL-[ ¹³C, 2-¹⁵N]arginine, 9, were synthesized. These were fed to cultures of Streptomyces griseochromogenes in order to probe the mechanism of the apparent arginine-2,3- aminomutase reaction occurring in biosynthesis of blasticidin S, 1. In previous studies of the enzymes lysine-2,3- aminomutase and tyrosine-2,3-aminomutase different...
Resource Type:: Masters Thesis
Full Text:: chool cli Date Thesis is presented March 28, 1985 ACKNOWLEDGMENTS I would like to thank Dr. Steven

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Wityak, John
Abstract:: The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
Resource Type:: Dissertation
Full Text:: F. Abstract Approved: Redacted for Privacy DrkSieven J. Gould The loss of all deuterium labels

Studies on advanced intermediates in the biosynthesis of streptonigrin

Creator:: Erickson, W. Randal
Abstract:: Early studies on the biosynthesis of the quinoline quinone portion of streptonigrin, 1, had suggested the intermediacy of novel aromatic amino acids. In order to test this hypothesis, a series of compounds was synthesized and tested for potential incorporation. [4-¹⁵N] 4-Aminoanthranilic acid, 4 5 a , [4-² H] 7-aminoquinaldinic acid,...
Resource Type:: Dissertation
Full Text:: Streptonigrin Abstract Approved: Redacted for privacy -Dr. Steven J. Gould Early studies on the biosynthesis

Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Creator:: Prabhakaran, P. C.
Abstract:: Feeding of [3-¹³C, 2-¹⁵N]arginine, 38a, unequivocally established that the β- arginine moiety of blasticidin S, 1, was formed from α-arginine by an intramolecular migration of the α-amino group to the β- position. Further feedings using chirally deuteriated arginines 38e and 38f revealed that the aminomutase process occurred with inversion of...
Resource Type:: Dissertation
Full Text:: Acknowledgements I would like to express my gratitude to Professor Steven J. Gould, my research director, for his

Biosynthesis of acivicin and 4-hydroxyacivicin

Creator:: Ju, Shyh-chen
Resource Type:: Dissertation
Full Text:: approved: Steven J. Gould In order to establish the biosynthetic pathway in Streptomyces sviceus leading

Studies of the biosynthesis of Sarubicin A

Creator:: Eisenberg, Rodney L.
Abstract:: Early studies on the biosynthesis of Sarubicin A, 1, had suggested the intermediacy of the novel aromatic amino acid 6-hydroxyanthranilic acid, 17. To investigate the biosynthetic steps beyond 17, [¹³C-¹⁵N carboxamide] 6-hydroxyanthranilamide, 27a, was synthesized, and fed to fermentations of Streptomyces helicus. Incorporation of 27a into 1 provided suggestive evidence...
Resource Type:: Dissertation
Full Text:: Privacy Dr. Steven \J.l Gould Early studies on the biosynthesis of Sarubicin A, 1, had suggested the

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Creator:: Shen, Ben
Resource Type:: Dissertation
Full Text:: approved: Ur. Steven J. Gould Antibiotic LL-C10037a, has now been shown to have the epoxysemiquinone

Syntheses of labeled putative intermediates in acivicin biosynthesis

Creator:: Jiang, Nan
Resource Type:: Masters Thesis
Full Text:: husband Xingjian and my parents Acknowledgments I am truly grateful to Professor Steven J. Gould, my

Studies on naphthyridinomycin biosynthesis

Creator:: He, Weixuan
Resource Type:: Dissertation
Full Text:: presented on May 20. 1992 Stud'estn Naphthyridinomycin Biosynthesis . Steven J. Gould in

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Creator:: Guo, Jincan
Resource Type:: Dissertation
Full Text:: and my mother I want to express my whole-hearted gratitude to Professor Steven J. Gould and all

ScholarsArchive@OSU

Metabolism of L-α-arginine in the biosynthesis of blasticidin S

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Studies on advanced intermediates in the biosynthesis of streptonigrin

Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Biosynthesis of acivicin and 4-hydroxyacivicin

Studies of the biosynthesis of Sarubicin A

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Syntheses of labeled putative intermediates in acivicin biosynthesis

Studies on naphthyridinomycin biosynthesis

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

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